Web15 mrt. 2015 · Purpose: BRAF-mutant metastatic colorectal cancer (mCRC) forms an aggressive subset of colorectal cancer with minimal response to selective RAF inhibitors. … Web22 jul. 2024 · Another Phase I study reported by Overman et al examined 2 TAS-102 dosing schedules. 40 In the 63 patients studied (52 with refractory mCRC), the recommended Phase II doses (RP2Ds) were 100 mg/m 2 /day administered once daily on days 1–5 and 8–12 of a 28-day cycle or 160 mg/m 2 /day once daily on days 1–5 of a 21-day cycle.
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